Positive selection of AS3MT to arsenic water in Andean populations
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چکیده
منابع مشابه
Positive selection of AS3MT to arsenic water in Andean populations
Arsenic is a carcinogen associated with skin lesions and cardiovascular diseases. The Colla population from the Puna region in Northwest Argentinean is exposed to levels of arsenic in drinking water exceeding the recommended maximum by a factor of 20. Yet, they thrive in this challenging environment since thousands of years and therefore we hypothesize strong selection signatures in genes invol...
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A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3MT) was expressed, and the purified enzyme was characterized. The synthetic enzyme is considerably more active than a cDNA-expressed enzyme using endogenous reductants thioredoxin (Trx), thioredoxin reductase (TR), NADPH, and reduced glutathione (GSH). Each of the seven cysteines (the four conserved residu...
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BACKGROUND Arsenic (As) occurs as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in humans, and the methylation pattern demonstrates large interindividual differences. The fraction of urinary MMA is a marker for susceptibility to As-related diseases. OBJECTIVES We evaluated the impact of polymorphisms in five methyltransferase genes on As metabolism in two populations, one in Sou...
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متن کاملEvolutionary Selection for Arsenic Resistance: The Case of the Atacameños of the Andes Highlands
In many locations the contamination of drinking water with inorganic arsenic has occurred relatively recently in evolutionary time. But in the Andes highlands, people have consumed water containing arsenic for at least several thousand years due to pre-Columbian mining activities and arsenic-tinged natural reservoirs; Andean mummies dating back 7,000 years have high arsenic concentrations in th...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 2015
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2015.07.007